Redskins beat Cowboys 28-18 to win NFC East

LANDOVER, Md. (AP) — "R-G-3!" was all Redskins fans needed to chant when they wanted to express their love for Robert Griffin III. For the lesser-known rookie, they opted for his whole name: "Alf-red Mor-ris!"

It's a new generation that has Washington atop the NFC East for the first time this millennium. There's Griffin — the vocal leader, the first-round draft pick, the Heisman Trophy winner, the team captain. And there's Morris — the out-of-nowhere sixth-rounder from Florida Atlantic who merely ran for 200 yards and three touchdowns in the division-clincher and broke the franchise single-season rushing record.

"These," cornerback DeAngelo Hall said, "aren't ordinary rookies."

The Redskins claimed their first division title since 1999, beating the archrival Dallas Cowboys 28-18 Sunday night in a winner-take-all finale to end the NFL's regular season.

"I was 9 years old in 1999," said Griffin, sporting a black baseball cap commemorating the title. "So I stand before you at 22, and the Redskins are the NFC East champions. To me, talking to Alfred after the game, it's the first time the Redskins have been champs since '99 and we came in and we did it in one year. The sky's the limit for this team."

Griffin, gradually regaining his explosiveness after spraining his right knee four weeks ago, ran for 63 yards and a touchdown for the Redskins (10-6), who finished with seven straight wins after their bye week. They became the first NFL team to rally from 3-6 and make the playoffs since the Jacksonville Jaguars in 1996.

With the running game working so well, Griffin didn't have to throw much. He completed nine of 18 passes for 100 yards.

Washington will host Seattle next Sunday, the Redskins' third consecutive playoff game against the Seahawks. They lost at Seattle as a wild-card team in the 2005 and 2007 seasons.

"I've been here for the 4-12, the bad times, almost being the joke of the NFL," veteran defensive lineman Kedric Golston said. "But to do this with this group of guys — the old and the new — it's good to be here."

Certainly, Sunday night was mostly about the new. Morris had touchdown runs of 1, 17 and 32 yards and was so dominant that the Cowboys — missing their five best run defenders due to injuries — fell hook, line and sinker nearly every time the Redskins faked the ball to him. He finished with 1,613 yards for the year, topping Clinton Portis' 1,516 in 2005.

"I'll tell you what: Alfred Morris became a star tonight," Redskins tight end Chris Cooley said. "He deserved it. He's a phenomenal football player."

To which Morris answered: "I'm never a star. I'll never be a star. Other people might think I'm a star, but I'm just Alfred."

He won't have much choice if he keeps this up. On the Redskins' go-ahead drive in the third quarter, six plays were runs by Morris and the other three involved fakes to him. The touchdown came when Griffin faked to Morris — one of several times linebacker DeMarcus Ware was totally fooled by deception in the backfield — and ran 10 yards around left end to put Washington ahead 14-7.

The Cowboys (8-8), meanwhile, will miss the playoffs for the third straight season, having stumbled in a make-or-break end-of-regular-season game for the third time in five years.

Tony Romo threw three interceptions — matching his total from the last eight games combined. A poor throw was picked by Rob Jackson when the Cowboys had a chance to drive for a winning score in the final minutes.

"I feel as though I let our team down," Romo said.

Romo completed 20 of 31 passes for 218 yards, and his career is now further tainted by post-Christmas disappointments, including Week 17 losses to the Philadelphia Eagles (44-6) in 2008 and the New York Giants (31-14) last year. He's also 1-3 in playoff games.

"Your legacy will be written when you're done playing the game," Romo said. "And when it's over with, you'll look back. ... It's disappointing not being able to get over that hump."

The Cowboys played catch-up after Morris' 32-yard scamper gave the Redskins a 21-10 cushion with 10:32 to play, pulling within three on a 10-yard pass to Kevin Ogletree and a 2-point conversion with 5:50 left. But Morris' third touchdown sealed the win with 1:09 remaining.

The Cowboys also dealt with in-game injuries to receivers Miles Austin (left ankle), Dez Bryant (back) and Dwayne Harris (lower leg). Bryant, who had a torrid second half of the season despite breaking his left index finger, had four catches for 71 yards.

Washington's slow start this season prompted coach Mike Shanahan to dismiss playoff hopes and declare the remaining seven games would determine which players would be on his team "for years to come."

Griffin and his teammates had other plans, and the coach quickly changed his tune. Now the Redskins will be playing in January.

"All odds were against us," Morris said. "But we believed in each other."

Notes: Griffin set two more NFL rookie records. His 102.4 passer rating topped Ben Roethlisberger's 98.1 in 2004, and his 1.3 percentage of passes intercepted is better than Charlie Batch's 1.98 in 1998. Griffin had already set the league mark for rushing yards by a rookie QB (815). ... The Redskins also set a franchise record for fewest turnovers in a season with 14, fewer even than the 1982 team that played only nine regular-season games because of a players strike.

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Chinese Firm Is Cleared to Buy American DNA Sequencing Company

Ramin Rahimian for The New York Times

DNA sequencing machines at Complete Genomics in California. The firm dismissed concerns about its acquisition.

The federal government has given national security clearance to the controversial purchase of an American DNA sequencing company by a Chinese firm.

The Chinese firm, BGI-Shenzhen, said in a statement this weekend that its acquisition of Complete Genomics, based in Mountain View, Calif., had been cleared by the federal Committee on Foreign Investment in the United States, which reviews the national security implications of foreign takeovers of American companies. The deal still requires antitrust clearance by the Federal Trade Commission.

Some scientists, politicians and industry executives had said the takeover represented a threat to American competitiveness in DNA sequencing, a technology that is becoming crucial for the development of drugs, diagnostics and improved crops.

The fact that the $117.6 million deal was controversial at all reflects a change in the genomics community.

A decade ago, the Human Genome Project, in which scientists from many nations helped unravel the genetic blueprint of mankind, was celebrated for its spirit of international cooperation. One of the participants in the project was BGI, which was then known as the Beijing Genomics Institute.

But with DNA sequencing now becoming a big business and linchpin of the biotechnology industry, international rivalries and nationalism are starting to move front and center in any acquisition.

Much of the alarm about the deal has been raised by Illumina, a San Diego company that is the market leader in sequencing machines. It has potentially the most to lose from the deal because BGI might buy fewer Illumina products and even become a competitor. Weeks after the BGI deal was announced, Illumina made its own belated bid for Complete Genomics, offering 15 cents a share more than BGI’s bid of $3.15. But Complete Genomics rebuffed Illumina, saying such a merger would never clear antitrust review.

Illumina also hired a Washington lobbyist, the Glover Park Group, to stir up opposition to the deal in Congress. Representative Frank R. Wolf, Republican of Virginia, was the only member of Congress known to have publicly expressed concern.

BGI and Complete Genomics point out that Illumina has long sold its sequencing machines — including a record-setting order of 128 high-end machines — to BGI without raising any security concerns. Sequencing machines have not been subject to export controls like aerospace equipment, lasers, sensors and other gear that can have clear military uses.

“Illumina has never previously considered its business with BGI as ‘sensitive’ in the least,” Ye Yin, the chief operating officer of BGI, said in a November letter to Complete Genomics that was made public in a regulatory filing. In the letter, Illumina was accused of “obvious hypocrisy.”

BGI and Complete said that Illumina was trying to derail the agreement and acquire Complete Genomics itself in order to “eliminate its closest competitor, Complete.”

BGI is already one of the most prolific DNA sequencers in the world, but it buys the sequencing machines it uses from others, mainly Illumina.

Illumina, joined by some American scientists, said it worried that if BGI gained access to Complete’s sequencing technology, the Chinese company might use low prices to undercut the American sequencing companies that now dominate the industry.

Some also said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information that could be used to develop drugs and diagnostic tests. Some also worried about protection of the privacy of genetic information.

“What’s to stop them from mining genomic data of American samples to some unknown nefarious end?” Elaine R. Mardis, co-director of the genome sequencing center at Washington University in St. Louis, said in an e-mail.

Dr. Mardis could not specify what kind of nefarious end she imagined. But opponents of the deal cited a November article in The Atlantic saying that in the future, pathogens could be genetically engineered to attack particular individuals, including the president, based on their DNA sequences.

BGI and Complete Genomics dismissed such concerns as preposterous.

Read More..

Chinese Firm Is Cleared to Buy American DNA Sequencing Company

Ramin Rahimian for The New York Times

DNA sequencing machines at Complete Genomics in California. The firm dismissed concerns about its acquisition.

The federal government has given national security clearance to the controversial purchase of an American DNA sequencing company by a Chinese firm.

The Chinese firm, BGI-Shenzhen, said in a statement this weekend that its acquisition of Complete Genomics, based in Mountain View, Calif., had been cleared by the federal Committee on Foreign Investment in the United States, which reviews the national security implications of foreign takeovers of American companies. The deal still requires antitrust clearance by the Federal Trade Commission.

Some scientists, politicians and industry executives had said the takeover represented a threat to American competitiveness in DNA sequencing, a technology that is becoming crucial for the development of drugs, diagnostics and improved crops.

The fact that the $117.6 million deal was controversial at all reflects a change in the genomics community.

A decade ago, the Human Genome Project, in which scientists from many nations helped unravel the genetic blueprint of mankind, was celebrated for its spirit of international cooperation. One of the participants in the project was BGI, which was then known as the Beijing Genomics Institute.

But with DNA sequencing now becoming a big business and linchpin of the biotechnology industry, international rivalries and nationalism are starting to move front and center in any acquisition.

Much of the alarm about the deal has been raised by Illumina, a San Diego company that is the market leader in sequencing machines. It has potentially the most to lose from the deal because BGI might buy fewer Illumina products and even become a competitor. Weeks after the BGI deal was announced, Illumina made its own belated bid for Complete Genomics, offering 15 cents a share more than BGI’s bid of $3.15. But Complete Genomics rebuffed Illumina, saying such a merger would never clear antitrust review.

Illumina also hired a Washington lobbyist, the Glover Park Group, to stir up opposition to the deal in Congress. Representative Frank R. Wolf, Republican of Virginia, was the only member of Congress known to have publicly expressed concern.

BGI and Complete Genomics point out that Illumina has long sold its sequencing machines — including a record-setting order of 128 high-end machines — to BGI without raising any security concerns. Sequencing machines have not been subject to export controls like aerospace equipment, lasers, sensors and other gear that can have clear military uses.

“Illumina has never previously considered its business with BGI as ‘sensitive’ in the least,” Ye Yin, the chief operating officer of BGI, said in a November letter to Complete Genomics that was made public in a regulatory filing. In the letter, Illumina was accused of “obvious hypocrisy.”

BGI and Complete said that Illumina was trying to derail the agreement and acquire Complete Genomics itself in order to “eliminate its closest competitor, Complete.”

BGI is already one of the most prolific DNA sequencers in the world, but it buys the sequencing machines it uses from others, mainly Illumina.

Illumina, joined by some American scientists, said it worried that if BGI gained access to Complete’s sequencing technology, the Chinese company might use low prices to undercut the American sequencing companies that now dominate the industry.

Some also said that with Complete Genomics providing an American base, BGI would have access to more DNA samples from Americans, helping it compile a huge database of genetic information that could be used to develop drugs and diagnostic tests. Some also worried about protection of the privacy of genetic information.

“What’s to stop them from mining genomic data of American samples to some unknown nefarious end?” Elaine R. Mardis, co-director of the genome sequencing center at Washington University in St. Louis, said in an e-mail.

Dr. Mardis could not specify what kind of nefarious end she imagined. But opponents of the deal cited a November article in The Atlantic saying that in the future, pathogens could be genetically engineered to attack particular individuals, including the president, based on their DNA sequences.

BGI and Complete Genomics dismissed such concerns as preposterous.

Read More..

Russia Says Bashar al-Assad Won’t Leave Syria

Sergei Karpukhin/Reuters

Russia’s foreign minister, Sergey V. Lavrov, right, spoke Saturday at a news conference with Lakhdar Brahimi, the United Nations and Arab League envoy on Syria.

MOSCOW — Russia’s foreign minister, Sergey V. Lavrov, said Saturday that there was “no possibility” of persuading President Bashar al-Assad to leave Syria, leaving little hope for a breakthrough in the standoff. He also said that the opposition leaders’ insistence on Mr. Assad’s departure as a precondition for peace talks would come at the cost of “more and more lives of Syrian citizens” in a conflict that has already killed tens of thousands.

Moscow has made a muscular push for a political solution in recent days, sending signals that the Kremlin, one of Mr. Assad’s most important allies, sees a pressing need for political change. As an international consensus forms around the notion of a transitional government, it has been snagged on the thorny question of what role, if any, Mr. Assad would occupy in it.

But after talks in Moscow on Saturday with Lakhdar Brahimi, the United Nations and Arab League envoy on Syria, Mr. Lavrov said that Russia could not press Mr. Assad to give up power. Mr. Lavrov has said that Russia “isn’t in the business of regime change,” but his characterization of Mr. Assad’s stance on Saturday sounded more definitive.

“He has repeatedly said, both publicly and privately, including during his meeting with Lakhdar Brahimi not long ago, that he has no plans to go anywhere, that he will stay in his post until the end, that he will, as he says, protect the Syrian people, Syrian sovereignty and so forth,” Mr. Lavrov said. “There is no possibility of changing this position.”

There have been evident changes in the standoff over Syria in recent weeks, as Russia acknowledged that government forces were losing territory and distanced itself from Mr. Assad. In televised remarks, President Vladimir V. Putin said that Russian leaders “are not preoccupied by the fate of Assad’s regime” and that after 40 years of rule by one family, “undoubtedly there is a call for change.”

But Moscow has watched the recent Arab uprisings with mounting worry, arguing that the West was unleashing dangerous turbulence by supporting popular rebellions, and it has vehemently opposed any international intervention in Syria as a matter of principle.

Developments on the battlefield have accelerated the pace of diplomacy.

Anti-Assad activists on Saturday reported fierce fighting and large numbers of casualties in the central city of Homs, where they said government troops were completely surrounding the Deir Ba’alba neighborhood after storming the area on Friday. An activist reached by telephone, who said he was less than a mile from the neighborhood on Saturday night, said he heard gunfire and saw houses in flames. Communications to the area had been cut, and civilians and rebel fighters who had managed to flee were “traumatized,” he said.

Mr. Brahimi, an Algerian statesman who is viewed sympathetically in Moscow, recommended last week that a transitional government be established, perhaps within months, and that it should rule Syria until elections could be held.

Like Russia, Mr. Brahimi hopes to arrange a political settlement on the basis of an international agreement reached this summer in Geneva, which envisages a transitional government and a peacekeeping force. But the Geneva document does not address Mr. Assad’s fate, nor does it invoke tough sanctions against the Syrian government under Chapter VII of the United Nations Charter, which authorizes economic measures and, if necessary, military action.

On Saturday, Mr. Brahimi said that it might be necessary to “make some small changes to the Geneva agreement.”

“Nonetheless,” he added, “I consider that it is a wonderful basis for the continuation of the political process.” He warned that if a political solution was not possible, Syria would be overrun by violence, like Somalia. He also said his recent visit to Damascus had convinced him that continued fighting in the country could turn into “something horrible,” and he envisioned the flight of a million people across Syria’s borders into Jordan and Lebanon.

“The problem could grow to such proportions that it could have a substantial effect on our future, and we cannot ignore this,” Mr. Brahimi said.

Russia has set the stage for forward momentum, announcing a gathering in mid-January between the United States, Russia and Mr. Brahimi to discuss Syria.

Moscow may see these talks as a chance to rebuild its prestige in the Arab world, where Russia’s historically strong alliances have been badly damaged by the standoff over Syria. Mr. Lavrov bridled on Saturday when a reporter from an Arabic news channel asked him to comment on criticism that Russia was “a participant in the Syrian conflict” because it continued to fulfill weapons contracts with Damascus after the outbreak of violence.

The accusation, Mr. Lavrov said, “is so far from the truth that there’s no way to comment on it.” He said that Russia did not supply the government with offensive weapons, and that much of Syria’s arsenal dated to the Soviet era. He also said the opposition was receiving a far more deadly flow of weapons and aid.

The leader of the main opposition coalition, Sheik Ahmad Moaz al-Khatib, responded coolly to an overture on Friday from Russia, saying Moscow should publicly apologize for its pro-government position. He also refused to meet with Russian leaders in Moscow, saying a meeting was possible only in an Arab country.

Mr. Lavrov said Saturday that he would agree to such a meeting, but he responded to Mr. Khatib’s remarks with an equally chilly response.

“I know that Mr. Khatib is probably not very experienced in politics,” he said. “If he aspires to the role of a serious politician, he will nonetheless understand that it is in his own interests to hear our analysis directly from us.”

Hwaida Saad contributed reporting from Beirut, Lebanon.

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Top Comments: The Problems with Facebook, Windows and Apple

The Problem with Windows 8

In the op-ed “The Problem with Windows 8″ Mashable editor Pete Pachal elaborated on the problems he has with Windows 8. Reader Xuanlong pointed out that Windows 8 had a tough act to follow in Windows 7, and that Windows 8 represents a necessary risk for Microsoft.

Click here to view this gallery.

[More from Mashable: Apple Spares Samsung Galaxy S III Mini From Patent Infringement Case]

As the holiday season and the year itself drew to a close this week, Mashable readers were reflective about the innovations and complications we’ve seen in the tech world in 2012. The top comments this week showcase the excitement and frustration that surround top products and services like Microsoft, Apple and Facebook.

The most commented upon story this week was was the op-ed “The Problem with Windows 8,” in which Mashable editor Pete Pachal elaborated on the problems he has with the new OS. Our readers largely agreed with Pachal’s assessment of Windows 8′s shortcomings, though several readers provided well-reasoned rebuttals of some of his points. The second-hottest story was about the rumored “smartphone watch” that Apple may be developing. Our community was split over whether or not this watch was something they wanted, or that anyone needed.

[More from Mashable: 3 Apple Computer Designs That You’ve Never Seen]

Readers also flocked to stories this week that looked at the intersection of human interaction and technology. Mark Zuckerberg’s sister Randi was outraged when a picture she posted on Facebook was reposted to Twitter, inciting a global online conversation about Facebook‘s privacy settings. Our commenters sounded off on everything from Randi Zuckerberg‘s reaction to Facebook’s settings themselves.

What was the topic on Mashable that you were most excited about this week? Don’t forget to let your voice be heard in the comment sections and next week you could be featured in the top comments.

It’s been a wonderful year for the Mashable community, and we want to thank all of our readers for making it fantastic. See you in 2013!

Image courtesy of Flickr, Nandor Fejer

This story originally published on Mashable here.

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Michigan State edges TCU 17-16 in BWW Bowl

TEMPE, Ariz. (AP) — Michigan State labored on offense throughout the first half, unable to get anything going on the ground, in the air, anywhere.

For a team that had lost five games by a combined 13 points during the regular season, it was starting to feel familiar.

The Spartans changed their luck by turning to brutally effective running back Le'Veon Bell in the second half, setting up Dan Conroy for another game-winning kick in a bowl game.

Bell ran for 145 yards and a fourth-quarter touchdown, Conroy kicked a 47-yard field goal with 1:01 left and Michigan State rallied to beat Texas Christian 17-16 in the Buffalo Wild Wings Bowl on Saturday night.

"With so many close games and losing like we did during the season, to have one go our way was definitely sweet," Conroy said.

It wasn't always pretty for the Spartans.

Michigan State (7-6) managed 76 yards of offense during the first two quarters as TCU bottled up Bell.

The 237-pound junior started to wear down the Horned Frogs in the second half, grinding out 107 of his yards on a 32-carry night.

Behind Bell, the Spartans went on the longest drive in their bowl history in the third quarter, marching 90 yards to set up freshman Connor Cook's 15-yard touchdown pass to Aaron Burbridge.

Michigan State then recovered a muffed punt by TCU's Skye Dawson at the 4-yard line midway through the fourth and Bell scored two plays later by racing around left end for a 14-13 lead.

TCU (7-6) still had a little life after blowing a 13-point halftime lead, moving just far enough to set up Jaden Oberkrom for the longest field goal in the bowl's history, a 53-yarder that put the Horned Frogs up 16-14 with 2:42 left.

They just left Michigan State too much time.

Starting at their own 25-yard line, the Spartans moved 45 yards in eight plays, setting up Conroy for his second game-winner in a bowl after beating Georgia with a 28-yarder in the third overtime of the 2012 Outback Bowl.

Michigan State's defense held after that, sending the Spartans to their second straight bowl win after three consecutive losses.

"There was no doubt in my mind that after so many losses in similar fashion that we were going to come out on top in this one," Spartans linebacker Max Bullough said.

The Horned Frogs shut down Michigan State's offense in the first half and did just enough when they had the ball to put together three scoring drives.

In the second half, TCU couldn't get anything going against the Spartans' defense — 84 total yards — and its defense gave up the long scoring drive in the third quarter, along with the game-winner in the fourth.

Trevone Boykin threw for 201 yards and an interception on 13-of-29 passing for the Horned Frogs.

"A little bit empty feeling inside because we felt like we left a lot on the field," TCU coach Gary Patterson said.

TCU and Michigan State came to the desert with an awful lot of similarities.

The Horned Frogs opened their first season in the Big 12 with four straight wins before losing four of their final six games. Michigan State started 4-2, then lost four of six down the stretch.

Michigan State had the nation's fourth-best defense and was 10th in scoring defense during the regular season. TCU was 18th in total defense and 10th against the run.

Michigan State quarterback Andrew Maxwell was up-and-down in his first season as Kirk Cousins' replacement, throwing 13 touchdown passes and nine interceptions. Boykin took over after four games for Casey Pachall, who was suspended and later left the team, and threw for 15 touchdowns and nine interceptions.

The biggest difference between the teams was Bell.

He ranked third nationally with 137.3 yards rushing per game and had 1,648 on the season, second-most in Michigan State history and 242 fewer than TCU had as a team.

Early on, the Horned Frogs gave him nowhere to go.

Filling holes inside and stringing plays out toward the sidelines, TCU stuffed the bruising Bell on nearly every touch, holding him to 38 yards on 11 carries in the first half.

Of course, it didn't seem to matter what Michigan State did. The Spartans had 29 yards on 12 plays in the first quarter and weren't a whole lot better in the second, with Maxwell throwing two near-interceptions on consecutive passes and an ill-advised trick play that probably should have resulted in a turnover, too.

The Spartans still seemed to be stuck in the ruts in the third quarter before grinding out a 14-play scoring drive led by Cook, who replaced Maxwell for the second time in the game. They had their biggest play on a floating pass from Bell to fullback TyQuan Hammock (29 yards), then Cook threw his first career touchdown pass, a 15-yarder to Burbridge on a crossing route that cut TCU's lead to 13-7.

"I thought Connor did a good job on the 90-yard drive, gave us a little momentum," Spartans coach Mark Dantonio said.

TCU didn't exactly have its way with Michigan State's defense in the first half and missed some chances to build a bigger lead.

The Frogs started gashing the Spartans for decent-sized chunks with their option midway through the first quarter, setting up Matthew Tucker's 4-yard touchdown on an end-around.

Boykin had an impressive off-the-back-foot throw to freshman Kolby Listenbee for 59 yards on the last play of the first quarter and nearly had a 19-yard touchdown pass to open the second, but LaDarius Brown was bumped and dropped the ball in the end zone. Oberkrom followed with a 47-yard field goal and added another from 31 yards after Boykin hit Josh Boyce on a 61-yard pass to put TCU up 13-0 at halftime.

The Frogs couldn't keep it up in the second half.

With Michigan State clogging the running lanes and chasing Boykin around, TCU had 30 yards of offense in the third quarter and continued to struggle in the fourth. The Horned Frogs did manage the short scoring drive to set up Oberkrom's late field goal, but ended up going backward on their final drive after Conroy's kick.

"What I thought happened in the third quarter was Michigan State dialed up the heat and we didn't have an answer," Patterson said.

Michigan State did — for one of the few times this season.

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Elwood V. Jensen, Pioneer in Breast Cancer Treatment, Dies at 92

Tony Jones/Cincinnati Enquirer, via Associated Press

Elwood V. Jensen in 2004.

Elwood V. Jensen, a medical researcher whose studies of steroid hormones led to new treatments for breast cancer that have been credited with saving or extending hundreds of thousands of lives, died on Dec. 16 in Cincinnati. He was 92.

The cause was complications of pneumonia, his son, Thomas Jensen, said.

In 2004 Dr. Jensen received the Albert Lasker Basic Medical Research Award, one of the most respected science prizes in the world.

When Dr. Jensen started his research at the University of Chicago in the 1950s, steroid hormones, which alter the functioning of cells, were thought to interact with cells through a series of chemical reactions involving enzymes.

However, Dr. Jensen used radioactive tracers to show that steroid hormones actually affect cells by binding to a specific receptor protein inside them. He first focused on the steroid hormone estrogen.

By 1968, Dr. Jensen had developed a test for the presence of estrogen receptors in breast cancer cells. He later concluded that such receptors were present in about a third of those cells.

Breast cancers that are estrogen positive, meaning they have receptors for the hormone, can be treated with medications like Tamoxifen or with other methods of inhibiting estrogen in a patient’s system, like removal of the ovaries. Women with receptor-rich breast cancers often go into remission when estrogen is blocked or removed.

By the mid-1980s, a test developed by Dr. Jensen and a colleague at the University of Chicago, Dr. Geoffrey Greene, could be used to determine the extent of estrogen receptors in breast and other cancers. That test became a standard part of care for breast cancer patients.

Scientists like Dr. Pierre Chambon and Dr. Ronald M. Evans, who shared the 2004 Lasker prize with Dr. Jensen, went on to show that many types of receptors exist. The receptors are crucial components of the cell’s control system and transmit signals in an array of vital functions, from the development of organs in the womb to the control of fat cells and the regulation of cholesterol.

Dr. Jensen’s work also led to the development of drugs that can enhance or inhibit the effects of hormones. Such drugs are used to treat prostate and other cancers.

Elwood Vernon Jensen was born in Fargo, N.D., on Jan. 13, 1920, to Eli and Vera Morris Jensen. He majored in chemistry at what was then Wittenberg College in Springfield, Ohio, and had begun graduate training in organic chemistry at the University of Chicago when World War II began.

Dr. Jensen wanted to join the Army Air Forces, but his poor vision kept him from becoming a pilot. During the war he synthesized poison gases at the University of Chicago, exposure to which twice put him in the hospital. His work on toxic chemicals, he said, inspired him to pursue biology and medicine.

Dr. Jensen studied steroid hormone chemistry at the Swiss Federal Institute of Technology on a Guggenheim Fellowship after the war. While there, he climbed the Matterhorn, one of the highest peaks in the Alps, even though he had no mountaineering experience. He often equated his successful research to the novel approach taken by Edward Whymper, the first mountaineer to reach the Matterhorn’s summit. Mr. Whymper went against conventional wisdom and scaled the mountain’s Swiss face, after twice failing to reach the summit on the Italian side.

Dr. Jensen joined the University of Chicago as an assistant professor of surgery in 1947, working closely with the Nobel laureate Charles Huggins. He became an original member of the research team at the Ben May Laboratory for Cancer Research (now the Ben May Department for Cancer Research) in 1951, and became the director after Dr. Huggins stepped down.

He came to work at the University of Cincinnati in 2002, and continued to do research there until last year.

His first wife, the former Mary Collette, died in 1982. In addition to his son, Dr. Jensen is survived by his second wife, the former Hiltrud Herborg; a daughter, Karen C. Jensen; a sister, Margaret Brennan; two grandchildren; and three great-grandchildren.

Dr. Jensen’s wife was found to have breast cancer in 2005. She had the tumor removed, he said in an interview, but tested positive for the estrogen receptor and was successfully treated with a medication that prevents estrogen synthesis.

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Senate Leaders Racing to Beat Fiscal Deadline

WASHINGTON — Senate leaders and their aides spent Saturday searching for a formula to extend tax cuts for most Americans that could win bipartisan support in the Senate and final approval in the fractious House by the new year, hoping to prevent large tax increases and budget cuts that could threaten the fragile economy.

As part of the last-minute negotiations, the lawmakers were haggling over unemployment benefits, cuts in Medicare payments to doctors, taxes on large inheritances and how to limit the impact of the alternative minimum tax, a parallel income tax system that is intended to ensure the rich pay a fair share but that is increasingly encroaching on the middle class.

President Obama said that if talks between the Senate leaders broke down, he wanted the Senate to schedule an up-or-down vote on a narrower measure that would extend only the middle-class tax breaks and unemployment benefits. The Senate majority leader, Harry Reid of Nevada, said he would schedule such a vote on Monday absent a deal.

If Congress is unable to act before the new year, Washington will effectively usher in a series of automatic tax increases and a program of drastic spending cuts that economists say could pitch the country back into recession.

The president and lawmakers put those spending cuts in place this year as draconian incentives that would force them to confront the nation’s growing debt. Now, lawmakers are trying to keep them from happening, though it seemed most likely on Saturday that the cuts, known as sequestration, would be left for the next Congress, to be sworn in this week.

“We just can’t afford a politically self-inflicted wound to our economy,” Mr. Obama said Saturday in his weekly address. “The housing market is healing, but that could stall if folks are seeing smaller paychecks. The unemployment rate is the lowest it’s been since 2008, but already families and businesses are starting to hold back because of the dysfunction they see in Washington.”

The fear of another painful economic slowdown appears to have accelerated deal-making on Capitol Hill with just 48 hours left before the so-called fiscal cliff arrives. Weeks of public sniping between Mr. Reid, the Democratic leader, and Senator Mitch McConnell of Kentucky, the Republican leader, ebbed on Friday evening with pledges of cooperation and optimism from both.

On Saturday, though, that sentiment was put to the test as 98 senators waited for word whether their leaders had come up with a proposal that might pass muster with members of both parties. The first votes in the Senate, if needed, are scheduled for Sunday afternoon.

“It’s a little like playing Russian roulette with the economy,” said Senator Mark Warner, Democrat of Virginia. “The consequences could be enormous.”

Members of Congress were mostly absent from the Capitol on Saturday, after two days of Senate votes on other matters and a day before both chambers were to reconvene. However, senior aides were working on proposals in their offices or at their homes.

Speaker John A. Boehner stopped by the Capitol briefly to see his chief of staff on Saturday afternoon. Mr. McConnell spent much of the day in his office.

Aides to Mr. Reid were expecting to receive offers from Mr. McConnell’s staff, but no progress was reported by midday. Even if the talks took a positive turn, Senate aides said, no announcement was expected before the leaders briefed their caucuses on Sunday.

The chief sticking point among lawmakers and the president continued to be how to set tax rates for the next decade and beyond. With the Bush-era tax cuts expiring, Mr. Obama and Democrats have said they want tax rates to rise on income over $250,000 a year, while Republicans want a higher threshold, perhaps at $400,000.

Democrats and Republicans are also divided on the tax on inherited estates, which currently hits inheritances over $5 million at 35 percent. On Jan. 1, it is scheduled to rise to 55 percent beginning with inheritances exceeding $1 million.

The political drama in Washington over the weekend was given greater urgency by the fear that the economic gains of the past two years could be lost if no deal is reached.

Some of the consequences of Congressional inaction would be felt almost at once on Tuesday, in employee paychecks, doctors’ offices and financial markets. Analysts said the effect would be cumulative, building over time.

An early barometer would probably be the financial markets, where skittish investors, as they have during previous Congressional cliffhangers, could send the stock market lower on fears of another prolonged period of economic distress.

In 2011, the political battles over whether to raise the nation’s borrowing limit prompted Standard & Poor’s to downgrade its rating of American debt, suggesting a higher risk of default. The Dow Jones industrial average fell 635 points in a volatile day of trading after the downgrade.

This month, traders have again nervously watched the political maneuvering in Washington, and the markets have jumped or dropped at tidbits of news from the negotiations. Two weeks ago, Ben S. Bernanke, the chairman of the Federal Reserve Board, predicted that if lawmakers failed to reach a deal, “the economy will, I think, go off the cliff.”

Immediately — regardless of whether a deal is reached — every working American’s taxes will go up because neither party is fighting to extend a Social Security payroll tax cut that has been in place for two years.

Robert Pear and Jennifer Steinhauer contributed reporting.

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The Saturday Profile: Maria Bashir, Afghan Prosecutor, Faces New Line of Attack Over Her Pursuit of ‘Moral Crimes’

Bryan Denton for The New York Times

“It is very difficult for a woman to work in Afghanistan, especially if you have an important position.”

MARIA BASHIR, the only woman serving as chief prosecutor in any of Afghanistan’s 34 provinces, does more than just walk the line between the progressive and the conservative — she has, uncomfortably, come to personify it.

Ms. Bashir, 42, is used to personal and even physical attacks from traditionalists because of her role as one of the country’s most senior female public officials and her work promoting women’s rights.

The outside world recognizes the ideal she represents as well as the dangers. Last year, in Washington, Michelle Obama and Secretary of State Hillary Rodham Clinton lauded her with a State Department International Women of Courage award.

“For uneducated men, but also even educated men, it is still very difficult to accept that a woman should be in a position of making decisions,” Ms. Bashir said, talking in her office tucked behind a gantlet of metal detectors and glowering security guards at the government compound in the western province of Herat.

But recently, Ms. Bashir has had to endure criticism of a less-familiar kind — that she has hurt women with her own conservatism.

Ms. Bashir’s office is jailing women for so-called moral crimes — like adultery, or even attempted adultery, an accusation that opens the door to being jailed merely for being alone with a man who is not in the family — at nearly the highest pace in Afghanistan, according to government records.

The country’s laws, though they have been changing over the past decade, are still criticized by human rights groups as being particularly harsh for women. And many women are languishing in jail on adultery convictions even though they were the victims of rape, forced into prostitution, or simply ran away from abusive homes.

Ms. Bashir insists that she must uphold the law of the land, even as she works to improve opportunities for Afghan women. But concern over her prosecution statistics this fall sent ripples through the human rights community in Afghanistan.

Most rights advocates express respect for her. Still, she has become the focus of a whole body of disquieting questions for international officials working here: How far should you support a woman who personally represents change but also consistently enforces customs that the West sees as discriminatory? How far and how long can you push another society to change, and when do you accept it and compromise?

In its way, too, her case restates the questions dogging the entire American involvement in Afghanistan: Is the United States here merely to fight the Taliban or rebuild the country along Western lines? And now that the United States has said it is leaving, what progress has really been won, and what will endure when it is gone?

Ms. Bashir knows how discrimination feels personally. She was a prosecutor in Herat, her husband’s home province, but had to give up her job when the Taliban came to power in the 1990s.

She went underground, furtively teaching women and girls from her neighborhood in her home.

AFTER the Taliban fell, she got her job back and has been the chief prosecutor in Herat for the past five years, and a focus of attention for the international community.

She has worked with the United Nations, giving lectures at high schools and universities titled, “If I Did It, You Can Do It, Too.” In those speeches, and in other settings both public and private, she urges Afghan girls and young women to expand their ambitions and strive for jobs outside the home as lawyers or doctors.

For many in this country, hers is an unwelcome message.

During a recent interview in her office, Ms. Bashir was methodical, even understated, as she discussed much of her work. But when the talk turned to the patriarchal society that dominates here, her eyes showed the fire that distinguishes her — and has helped her survive — in a place where women in powerful posts are rare.

“We have the mullahs, we have the former jihadis,” she said. “They don’t spare any effort to weaken or defame you. They talk about your clothes; they talk about the fact you have been talking to foreigners and talking to men.”

Habib Zahori and Jawad Sukhanyar contributed reporting from Kabul, Afghanistan.

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