Well: Long Term Effects on Life Expectancy From Smoking

It is often said that smoking takes years off your life, and now a new study shows just how many: Longtime smokers can expect to lose about 10 years of life expectancy.

But amid those grim findings was some good news for former smokers. Those who quit before they turn 35 can gain most if not all of that decade back, and even those who wait until middle age to kick the habit can add about five years back to their life expectancies.

“There’s the old saw that everyone knows smoking is bad for you,” said Dr. Tim McAfee of the Centers for Disease Control and Prevention. “But this paints a much more dramatic picture of the horror of smoking. These are real people that are getting 10 years of life expectancy hacked off — and that’s just on average.”

The findings were part of research, published on Wednesday in The New England Journal of Medicine, that looked at government data on more than 200,000 Americans who were followed starting in 1997. Similar studies that were done in the 1980s and the decades prior had allowed scientists to predict the impact of smoking on mortality. But since then many population trends have changed, and it was unclear whether smokers today fared differently from smokers decades ago.

Since the 1960s, the prevalence of smoking over all has declined, falling from about 40 percent to 20 percent. Today more than half of people that ever smoked have quit, allowing researchers to compare the effects of stopping at various ages.

Modern cigarettes contain less tar and medical advances have cut the rates of death from vascular disease drastically. But have smokers benefited from these advances?

Women in the 1960s, ’70s and ’80s had lower rates of mortality from smoking than men. But it was largely unknown whether this was a biological difference or merely a matter of different habits: earlier generations of women smoked fewer cigarettes and tended to take up smoking at a later age than men.

Now that smoking habits among women today are similar to those of men, would mortality rates be the same as well?

“There was a big gap in our knowledge,” said Dr. McAfee, an author of the study and the director of the C.D.C.’s Office on Smoking and Public Health.

The new research showed that in fact women are no more protected from the consequences of smoking than men. The female smokers in the study represented the first generation of American women that generally began smoking early in life and continued the habit for decades, and the impact on life span was clear. The risk of death from smoking for these women was 50 percent higher than the risk reported for women in similar studies carried out in the 1980s.

“This sort of puts the nail in the coffin around the idea that women might somehow be different or that they suffer fewer effects of smoking,” Dr. McAfee said.

It also showed that differences between smokers and the population in general are becoming more and more stark. Over the last 20 years, advances in medicine and public health have improved life expectancy for the general public, but smokers have not benefited in the same way.

“If anything, this is accentuating the difference between being a smoker and a nonsmoker,” Dr. McAfee said.

The researchers had information about the participants’ smoking histories and other details about their health and backgrounds, including diet, alcohol consumption, education levels and weight and body fat. Using records from the National Death Index, they calculated their mortality rates over time.

People who had smoked fewer than 100 cigarettes in their lifetimes were not classified as smokers. Those who had smoked at least 100 cigarettes but had not had one within five years of the time the data was collected were classified as former smokers.

Not surprisingly, the study showed that the earlier a person quit smoking, the greater the impact. People who quit between 25 and 34 years of age gained about 10 years of life compared to those who continued to smoke. But there were benefits at many ages. People who quit between 35 and 44 gained about nine years, and those who stopped between 45 and 59 gained about four to six years of life expectancy.

From a public health perspective, those numbers are striking, particularly when juxtaposed with preventive measures like blood pressure screenings, colorectal screenings and mammography, the effects of which on life expectancy are more often viewed in terms of days or months, Dr. McAfee said.

“These things are very important, but the size of the benefit pales in comparison to what you can get from stopping smoking,” he said. “The notion that you could add 10 years to your life by something as straightforward as quitting smoking is just mind boggling.”

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Media Decoder Blog: A Resurgent Netflix Beats Projections, Even Its Own

9:12 p.m. | Updated For all those who have doubted its business acumen, Netflix had a resounding answer on Wednesday: 27.15 million.

That’s the number of American homes that were subscribers to the streaming service by the end of 2012, beating the company’s own projections for the fourth quarter after a couple of quarters of underwhelming results.

Netflix’s growth spurt in streaming — up by 2.05 million customers in the United States, from 25.1 million in the third quarter — was its biggest in nearly three years, and helped the company report net income of $7.9 million, surprising many analysts who had predicted a loss.

The results reflected just how far Netflix has come since the turbulence of mid-2011, when its botched execution of a new pricing plan for its services — streaming and DVDs by mail — resulted in an online flogging by angry customers. Investors battered its stock price, sending it from a high of around $300 in 2011 to as low as $53 last year.

“It’s risen from the ashes,” said Barton Crockett, a senior analyst at Lazard Capital Markets. “A lot of investors have been very skeptical that Netflix will work. With this earnings report, they’re making a strong argument that the business is real, that it will work.”

Investors, cheered by the results, sent Netflix shares soaring more than 35 percent in after-hours trading Wednesday. The stock had ended regular trading at $103.26.

Netflix’s fourth-quarter success was a convenient reminder to the entertainment and technology industries that consumers increasingly want on-demand access to television shows and movies. Streaming services by Amazon, Hulu and Redbox are all competing on the same playing field, but for now Netflix remains the biggest such service, and thus a pioneer for all the others.

“Our growth and our competitors’ growth shows just how large the opportunity is for Internet TV, where people get to control their viewing experience,” Netflix’s chief executive, Reed Hastings, said in a telephone interview Wednesday evening.

Questions persist, though, about whether Netflix will be able to attract enough subscribers to keep paying its ever-rising bills to content providers, which total billions of dollars in the years to come. The company said on Wednesday that it might take on more debt to finance more original programs, the first of which, the political thriller “House of Cards,” will have its premiere on the service on Feb. 1. Netflix committed about $100 million to make two seasons of “House of Cards,” one of five original programs scheduled to come out on the service this year.

“The virtuous cycle for us is to gain more subscribers, get more content, gain more subscribers, get more content,” Mr. Hastings said in an earnings conference call.

The company’s $7.9 million profit for the quarter represented 13 cents a share, surprising analysts who had expected a loss of 12 cents a share. The company said revenue of $945 million, up from $875 million in the quarter in 2011, was driven in part by holiday sales of new tablets and television sets.

Netflix added nearly two million new subscribers in other countries, though it continued to lose money overseas, as expected, and said it would slow its international expansion plans in the first part of this year.

The “flix” in Netflix, its largely forgotten DVD-by-mail business, fared a bit better than the company had projected, posting a loss of just 380,000 subscribers in the quarter, to 8.22 million. The losses have slowed for four consecutive quarters, indicating that the homes that still want DVDs really want DVDs.

On the streaming side, Netflix’s retention rate improved in the fourth quarter, suggesting growing customer satisfaction.

Asked whether the company’s reputation had fully recovered after its missteps in 2011, Mr. Hastings said, “We’re on probation at this point, but we’re not out of jail.”

He has emphasized subscriber happiness, even going so far as to say on Wednesday that “we really want to make it easy to quit” Netflix. If the exit door is well marked, he asserted, subscribers will be more likely to come back.

The hope is that original programs like “House of Cards” and “Arrested Development” will lure both old and new subscribers to the service. Those programs, plus the film output deal with the Walt Disney Company announced in December, affirm that Netflix cares more and more about being a gallery — with showy pieces that cannot be seen anywhere else — and less about being a library of every film and TV show ever made.

“They’re morphing into something that people understand,” said Mr. Crockett of Lazard Capital.

Mr. Hastings said this had been happening for years, but that it was becoming more apparent now to consumers and investors.

Mr. Hastings’s letter to investors brought up the elephant in the room, the activist investor Carl C. Icahn, who acquired nearly 10 percent of the company’s stock last October. Mr. Icahn, known for his campaigns for corporate sales and revampings, stated then that Netflix “may hold significant strategic value for a variety of significantly larger companies.”

Netflix subsequently put into place a shareholder rights plan, known as a poison pill, to protect itself against a forced sale by Mr. Icahn.

The company said on Wednesday, “We have no further news about his intentions, but have had constructive conversations with him about building a more valuable company.”

Factoring in the stock’s 30 percent rise since November and the after-hours action on Wednesday, Mr. Icahn’s stake has now more than doubled in value, to more than $700 million from roughly $320 million.

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India Ink: At This Year's Jaipur Lit Fest, Feminism, the Dalai Lama and Cricket

NEW DELHI —– It is that time of year again when the pink city of Jaipur in Rajasthan State warms up to host a carefully curated panel of literary greats from across the globe for the Jaipur Literature Festival, South Asia’s biggest annual literary event. In its sixth year now, the five-day event will kick off on Thursday at the majestic Diggi Palace, where 283 writers will appear before an audience of several thousand people and engage them through conversations and book readings.

The runup to the festival has not been without controversy. The Hindu right-wing group RSS and the national opposition Bharatiya Janata Party are demanding a ban on the participation of Pakistani writers in the wake of the recent skirmish along the Line of Control between India and Pakistan. And Muslim clerics have threatened to agitate if any of the four authors who last year read out excerpts from Salman Rushdie’s banned book ‘The Satanic Verses’ are seen at this year’s festival. Of the four, only the novelist Jeet Thayil is on the speaker’s list this time.

Organizers said that these threats would not affect the festival’s schedule.

“The media should not give space to this kind of rabble-rousing,” said Sanjoy K. Roy, the festival’s producer.  He said the venue was already secure, with more than 200 security personnel, and added that there was no need for any additional security.

A day ahead of the official opening, on Wednesday, an unlikely marriage of cricket and literature is culminating in a friendly game between authors and cricket players on the home turf of one of India’s premier league teams, the Rajasthan Royals. It will be ‘Royals XI’ versus ‘Authors XI’.

This year the festival is more “multilingual and multivocal” than the previous editions, said Namita Gokhale, one of the directors of the festival.

Writings in 17 Indian languages, including Bangla, Bhojpuri, Gujarati, Tamil and Kashmiri, will be showcased at the multilingual sessions that will offer a flavor of regional literary history as well as folk literature. Santhali, a language spoken in India’s east coast, will be represented at the festival for the first time. There will also be readings of literature in several foreign languages, including Spanish, French, Italian, as well as in Sinhala, spoken by the ethnic Sinhalese majority in Sri Lanka and in Dzongkha, the national language of Bhutan.

The idea of the festival is to show “India to the world and the world to India,” said William Dalrymple, the festival’s co-director.

The overarching theme of this year’s festival, which features 174 sessions, is Buddha in literature.

Spirituality has been central to literature in India, said Mr. Dalrymple, adding, “Buddhist literature has influenced so much of Asian literature.”

Complementing the theme, the big surprise guest this year is his holiness the Dalai Lama. The Tibetan leader, who is living in exile in India, will hold a conversation with the British-born novelist Pico Iyer on Thursday afternoon in a session titled “Kinships of Faiths.”

After the brouhaha last year over Oprah Winfrey’s star-spangled reception, the selection of this year’s chief guest seems to have been tempered on purpose.

“Oprah’s appearance sucked the oxygen from the other sessions,” Mr. Dalrymple said. “She took so much press.” Some of the other big names like Tom Stoppard, “one of the best playwrights” did not get the attention that he should have received last year.

Nonetheless, he said this year’s guest list is still spectacular.

Among those appearing are several award-winning authors, including the Commonwealth Prize Winner Aminatta Forna from Sierra Leone, Howard Jacobson, a Booker Prize winning author, and Andrew Solomon, a Pulitzer winner.

The historical novelist Lawrence Norfolk will be introduced to Indian book lovers for the first time along with other popular British writers including Sebastian Faulks and Deborah Moggach.

Mr. Dalrymple pointed out that several prominent authors from the Arab world are participating in the festival, including the Egyptian novelist Ahdaf Soueif and the Moroccon writer Tahar Ben Jalloun.

An emphasis on feminist writing and featuring women’s voices would seem to be a natural choice for the organizers after the recent spate of protests against sexual harassment of women in India.

“It wasn’t by design, but by instinct,” Ms. Gokhale said, noting planning for the event began in March last year.

Mahasweta Devi, an octogenarian Bengali writer and social activist, who will make her first appearance at the festival, has been on the organizers’ wish list for each of the past few years. A Tamil feminist writer who writes under the pseudonym Ambai will also be making her first appearance.

Diana L. Eck, a religious scholar form Harvard, and Gayatri Chakravorty Spivak, a postmodern and postcolonial theorist from Columbia, are among the distinguished women scholars scheduled to speak at the festival.

“The strand of sessions on ‘The Buddha in Literature’ examines the role of women in the Buddhist theology and hierarchy,” Ms. Gokhale explained. Other session including “Imagine: Resistance, Protest, Assertion” emphasize the “inspirational surge of women’s solidarity,” she said.

The phenomenal growth of the festival over the years has led the organizers to add another venue, the Char Bagh to the existing venues at the Diggi Palace to accommodate the crowds. Mr. Roy, the festival producer, said that 22,000 people can be accommodated per hour, up from 14,000 last year. A total of 122,000 people attended last year.

The festival organizers have spent an estimated 56 million rupees (about $1 million) this year. While Teamwork Productions, which is overseeing the event, is struggling to break even, the event will continue to be egalitarian and open to all without an admission fee, said Mr. Roy, who is also the managing director of the company. “Arts create wealth in a different way,” he said.

Chiki Sarkar, the publisher of Penguin Books India, uses the annual festival to launch a featured new book or talent. This year will see the launch of Anjan Sundaram, the author of “Stringer: A Reporter’s Journey in the Congo.”

“Very often projects that I have been thinking about for a while get crystallized in Jaipur,” she said.

Festival regulars say that much of the magic of the Jaipur Literature Festival takes place outside the sessions themselves. “The best thing is the surprise element, the random encounter that can result in something completely unexpected, new, and sometimes wonderful,” said Urvashi Butalia, a publisher and writer who is the co-founder of Kali for Women, India’s first feminist publishing house and the director of Zubaan, an imprint of Kali.

At least 20 parties will be hosted during the festival and 145 artists are expected to perform through the course of the five-day event, including Indian folk artists and Spanish performers.

(Neha Thirani contributed reporting.)

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FTC study taking aim at online marketing of booze and kids

LOS ANGELES (Reuters) – The Federal Trade Commission (FTC) plans this summer to recommend ways that the alcoholic beverage industry can better protect underage viewers from seeing its advertisements online.

Distillers, brewers and wineries pour millions of dollars into brand promotion on Twitter, Facebook and other social media, and industry critics contend they are not doing enough to prevent young consumers from receiving these messages.

“We’re doing a deep dive on how they’re using the Internet and social media,” said Janet Evans, a lawyer with the FTC, which is conducting a year-long study due to be released by early summer. “We’re focusing on underage exposure.”

She would not elaborate on any potential recommendations that might come out of the study, which began in April 2012.

The FTC is reviewing data from 14 big producers, Evans said, including Beam Inc, the maker of Jim Beam, Diageo Plc, home to Johnnie Walker, and Constellation Brands Inc, which makes Robert Mondavi and Ravenswood wines.

The FTC report “is something we take seriously and place at high priority,” said Karena Breslin, director for digital marketing at Constellation.

The FTC has made two requests for information since the study began, she said.

The regulatory agency has not said it intends to impose restrictions on liquor company social media advertising but it can make recommendations to the industry.

The FTC is empowered to file suit to ensure consumers are protected from deceptive marketing practices, Evans said, but she stressed that studies of this nature are meant to promote better self-regulation, not provide a basis for a case.

Executives say alcohol makers and distributors voluntarily adhere to the same industry-set standard for marketing to underage viewers on social media sites that the industry set for its ads on TV and other medium. That requires that at least 71.6 percent of an audience consists of adults 21 and older.

“No one in their right mind would want to advertise to people who can’t legally buy their product,” said Frank Coleman, senior vice president for Distilled Spirits Council of the United States (DISCUS), the trade group that sets the industry’s advertising codes.

In June 2011, DISCUS revised its code upwards to 71.6 percent from 70 percent, after the FTC recommended it review the standard to better reflect U.S. Census population data.

Industry critics, including David Jernigen, director of the Center on Alcohol Marketing and Youth at Johns Hopkins University, and Sarah Mart, research director of the advocacy group Alcohol Justice, contend the industry didn’t go far enough and should raise the standard further.

Jernigen says it needs to be at least 85 percent to effectively protect youth, so there would be no more than 15 percent exposure to the underage drinking population.

“The industry says its self-regulating but it’s ineffective and social media opens up a whole new set of problems because their ads are everywhere,” said Sarah Mart, research director for the San Rafael, Calif.-based group Alcohol Justice.

The industry group’s Coleman said the group now requires members to install age-checking tools via instant-messaging as a gateway to Twitter feeds and other branded Web platforms that ask the user for a birth date before admitting them.

In the first nine months of 2012, beer, wine and spirits manufacturers’ spent an estimated $ 35 million for paid Web display advertising, but industry executives estimate many millions more were spent on Web site creation, video production for platforms like Google’s YouTube and social media marketing efforts.

“We’ve significantly adjusted more money to digital for online video, Web sites, Facebook and Twitter content,” said Kevin George, global chief marketing officer for Jim Beam, which he says spends 30 percent of its media spend for online outlets, up from 10 percent in 2008.

Many companies are expanding their digital staff. Wine maker Constellation hired Breslin three years ago to initiate digital marketing and now has a team of five reporting to her.

Many alcoholic beverage companies flocked to Facebook because it requires users to post their birth dates when signing up. Last year Twitter partnered with Buddy Media to offer a more effective screening tool that sends a direct message to fans who click on a brand. The message sends the fan a link to a site that asks for date of birth, which has allowed Twitter to grab some more of the sector marketing. Salesforce.com bought Buddy Media last June, which is now folding the platform into its marketing cloud portfolio.

Health advocates and industry critics are crying foul. “Facebook and other interactive platforms are poorly monitored and not well age protected,” said Jernigen of Johns Hopkins University. “Anyone can say they’re 21 and click yes.”

(Reporting By Susan Zeidler; Editing by Ron Grover and Alden Bentley)

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Williams loses in quarters; Azarenka into semis

MELBOURNE, Australia (AP) — Serena Williams' dominating run at the majors ended in a painful loss to American teenager Sloane Stephens.

After the biggest victory of her life, the 19-year-old Stephens is headed to the semifinals of the Australian Open.

Williams hurt her back in the eighth game of the second set, slowing down her serve, restricting her movement and causing her obvious pain.

Stephens kept her composure, blocking out the injury issue on the opposite side of the net, and rallied for a 3-6, 7-5, 6-4 victory on Wednesday — by far the most significant in her seven Grand Slams.

The gravity of it didn't hit Stephens until she was warming down, and even then the victory had an unreal feeling.

"I was stretching, and I was like, 'I'm in the semis of a Grand Slam.' I was like, 'Whoa. It wasn't as hard as I thought.' But it's pretty cool," she said. "To be in the semis of a Grand Slam is definitely I say a good accomplishment. A lot of hard work."

It was Williams' first loss since Aug. 17, ending a run of 20 consecutive wins.

The 15-time major winner hadn't lost a match at a Grand Slam tournament since the French Open, where her first-round exit sparked her resurgence in the second half of 2012 that included titles at Wimbledon, the London Olympics, the U.S. Open and the WTA Championship.

After winning her first Grand Slam quarterfinal, Stephens next plays defending champion Victoria Azarenka.

In the men's draw, U.S. Open champion Andy Murray moved into the semifinals with a 6-4, 6-1, 6-2 win over unseeded Jeremy Chardy of France.

The No. 29-seeded Stephens had been given barely a chance of beating Williams, who lost only four matches in 2012 and was in contention to regain the No. 1 ranking at the age of 31.

Williams' latest winning streak included a straight-sets win over Stephens at the Brisbane International earlier this month.

And Stephens wasn't even sure that she could beat Williams, until she woke up Wednesday.

"When I got up, I was like, 'Look, Dude, like, you can do this.' Like, 'Go out and play and do your best," she said.

It wasn't until after losing the first set and being broken in the first game of the second that she really convinced herself she could.

"I was like, 'Hmm, this is not the way you want it to happen. But you just fight and just get every ball back, run every ball down, and just get a lot of balls in play, I think you'll be OK.'

"From then on I got aggressive, started coming to the net more, and just got a lot more comfortable."

She started hitting winners, cutting down on the errors, and pushing the injured Williams around the court.

Williams walked around the net to congratulate Stephens, who then clapped her hand on her racket and waved to the crowd, a look of disbelief on her face.

She then went to her tennis bag, pulled out her phone and started checking for any text messages from her mother.

"I was hoping she had texted me right away. I thought maybe she was texting me during the match," Stephens said. "I'm sure my grandparents are like freaking out."

Stephens has said she had a photo of Williams up in her room when she was a child, and had long admired the Williams sisters.

"This is so crazy. Oh my goodness," Stephens said, wiping away tears in her post-match TV interview. "I think I'll put a poster of myself (up) now."

For her part, Williams said the bad back was just another problem to contend with at a Grand Slam event that had been "absolutely" her worst for injuries. It started when she injured her ankle in the first round.

"I'm almost relieved that it's over because there's only so much I felt I could do," she said. "It's been a little difficult. I've been thrown a lot of (curve) balls these two weeks."

Williams was up a set and a break before Stephens settled in. In the eighth game of the second set, Williams was chasing a drop shot to the net when she appeared to hurt her back. She needed a medical timeout after the set, and then slowly started to regain the speed in her serve.

She said her back "just locked up" on her.

"I couldn't really rotate after that," she said. "It was a little painful, but it's OK."

There were times when she barely concealed the pain, and had to bend over or stretch out her back. Yet the thought of retiring from the match only crossed her mind "for a nanosecond."

It didn't mean she wasn't frustrated. Williams smashed her racket into the court in the third set, breaking the frame and then flinging it toward the chairs on the side of the court. She looked to the sky occasionally and yelled at herself.

The racket abuse cost her $1,500 in fines.

Azarenka, with her most famous fan sitting in the crowd wearing a shirt reminding her to keep calm, overcame some early jitters to beat Svetlana Kuznetsova 7-5, 6-1 in the earlier quarterfinal at Rod Laver Arena.

After dropping serve in a long fourth game that went to deuce 10 times, Azarenka recovered to dominate the rest of the match against Kuznetsova, a two-time major winner who was floating dangerously in the draw with a No. 75 ranking as she recovers from a knee injury.

Azarenka's American rapper friend, Redfoo, returned from a concert in Malaysia to attend Wednesday's quarterfinal.

Wearing a red sleeveless T-shirt that read "Keep Calm and Bring Out the Bottles," the name of his next single, Redfoo stood, clapped and yelled "Come on, Vika!" during the tight first set.

Asked if it helped to have her No. 1 fan wearing a keep calm logo, Azarenka said "I was looking more at the part that says 'Bring out the bottles.'"

Of her game, she added, "I'm just glad I could produce my good tennis when it was needed."

Williams' loss was a boost for Azarenka, who lost all five head-to-heads against the American in 2012 and is 1-11 in their career meetings.

In the men's quarterfinals, 17-time major winner Roger Federer was playing No. 7 Jo-Wilfried Tsonga in a night match for a spot in the semifinals against Murray.

The 25-year-old Murray had his service broken for only the second time while serving for the match. But he broke back immediately to clinch the quarterfinal victory.

"I'll watch a little bit but I won't watch the whole match," Murray said of the night quarterfinal, adding that he hoped "Roger and Jo play 4 to 5 hours if possible!"

Defending champion Novak Djokovic plays No. 4-seeded David Ferrer in the other semifinal.

On the other half of the women's draw, Maria Sharapova has conceded only nine games in five matches — a record in Australia — en route to a semifinal against 2011 French Open champion Li Na.

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Well: Is There an Ideal Running Form?

In recent years, many barefoot running enthusiasts have been saying that to reduce impact forces and injury risk, runners should land near the balls of their feet, not on their heels, a running style that has been thought to mimic that of our barefoot forebears and therefore represent the most natural way to run. But a new study of barefoot tribespeople in Kenya upends those ideas and, together with several other new running-related experiments, raises tantalizing questions about just how humans really are meant to move.

For the study, published this month in the journal PLoS One, a group of evolutionary anthropologists turned to the Daasanach, a pastoral tribe living in a remote section of northern Kenya. Unlike some Kenyan tribes, the Daasanach have no tradition of competitive distance running, although they are physically active. They also have no tradition of wearing shoes.

Humans have run barefoot, of course, for millennia, since footwear is quite a recent invention, in evolutionary terms. And modern running shoes, which typically feature well-cushioned heels that are higher than the front of the shoe, are newer still, having been introduced widely in the 1970s.

The thinking behind these shoes’ design was, in part, that they should reduce injuries. When someone runs in a shoe with a built-up heel, he or she generally hits the ground first with the heel. With so much padding beneath that portion of the foot, the thinking went, pounding would be reduced and, voila, runners wouldn’t get hurt.

But, as many researchers and runners have noted, running-related injuries have remained discouragingly common, with more than half of all runners typically being felled each year.

So, some runners and scientists began to speculate a few years ago that maybe modern running shoes are themselves the problem.

Their theory was buttressed by a influential study published in 2010 in Nature, in which Harvard scientists examined the running style of some lifelong barefoot runners who also happened to be from Kenya. Those runners were part of the Kalenjin tribe, who have a long and storied history of elite distance running. Some of the fastest marathoners in the world have been Kalenjin, and many of them grew up running without shoes.

Interestingly, when the Harvard scientists had the Kalenjin runners stride over a pressure-sensing pad, they found that, as a group, they almost all struck the ground near the front of their foot. Some were so-called midfoot strikers, meaning that their toes and heels struck the ground almost simultaneously, but many were forefoot strikers, meaning that they landed near the ball of their foot.

Almost none landed first on their heels.

What the finding seemed to imply was that runners who hadn’t grown up wearing shoes deployed a noticeably different running style than people who had always worn shoes.

And from that idea, it was easy to conjecture that this style must be better for you than heel-striking, since presumably it was more natural, echoing the style that early, shoeless cavemen would have used.

But the new study finds otherwise. When the researchers had the 38 Daasanach tribespeople run unshod along a track fitted, as in the Harvard study, with a pressure plate, they found that these traditionally barefoot adults almost all landed first with their heels, especially when they were asked to run at a comfortable, distance-running pace. For the group, that pace averaged about 8 minutes per mile, and 72 percent of the volunteers struck with their heels while achieving it. Another 24 percent struck with the midfoot. Only 4 percent were forefoot strikers.

When the Daasanach volunteers were asked to sprint along the track at a much faster speed, however, more of them landed near their toes with each stride, a change in form that is very common during sprints, even in people who wear running shoes. But even then, 43 percent still struck with their heels.

This finding adds to a growing lack of certainty about what makes for ideal running form. The forefoot- and midfoot-striking Kalenjin were enviably fast; during the Harvard experiment, their average pace was less than 5 minutes per mile.

But their example hasn’t been shown to translate to other runners. In a 2012 study of more than 2,000 racers at the Milwaukee Lakefront Marathon, 94 percent struck the ground with their heels, and that included many of the frontrunners.

Nor is it clear that changing running form reduces injuries. In a study published in October scientists asked heel-striking recreational runners to temporarily switch to forefoot striking, they found that greater forces began moving through the runners’ lower backs; the pounding had migrated from the runners’ legs to their lumbar spines, and the volunteers reported that this new running form was quite uncomfortable.

But the most provocative and wide-ranging implication of the new Kenyan study is that we don’t know what is natural for human runners. If, said Kevin G. Hatala, a graduate student in evolutionary anthropology at George Washington University who led the new study, ancient humans “regularly ran fast for sustained periods of time,” like Kalenjin runners do today, then they were likely forefoot or midfoot strikers.

But if their hunts and other activities were conducted at a more sedate pace, closer to that of the Daasanach, then our ancestors were quite likely heel strikers and, if that was the case, wearing shoes and striking with your heel doesn’t necessarily represent a warped running form.

At the moment, though, such speculation is just that, Mr. Hatala said. He and his colleagues plan to collaborate with the Harvard scientists in hopes of better understanding why the various Kenyan barefoot runners move so differently and what, if anything, their contrasting styles mean for the rest of us.

“Mostly what we’ve learned” with the new study, he said, “is how much still needs to be learned.”

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DealBook: Allergan to Buy MAP Pharmaceuticals for $958 Million

Allergan has agreed to pay nearly $1 billion to acquire MAP Pharmaceuticals and gain full control of its experimental treatment for migraine headaches, the two companies announced Tuesday night.

The purchase price of $25 a share in cash is a 60 percent premium over MAP’s closing price on Tuesday of $15.58 a share. The deal, valued at $958 million in total, suggests that Allergan has considerable faith that MAP’s new migraine treatment will win regulatory approval from the Food and Drug Administration by the agency’s deadline of April 15.

The two companies said the deal had been unanimously approved by the boards of both companies and was expected to close in the second quarter.

Allergan already had the rights to help market the migraine drug, known as Levadex, in the United States and Canada, but after an acquisition it would have control of all the profits and costs globally.

Allergan is most known for Botox, a form of the botulinum toxin, which is used for cosmetic purposes as well as medical ones, including the treatment of chronic migraines with the goal of reducing the frequency of headaches. By contrast, Levadex is meant to treat migraines after they occur, making it complementary to Botox, Allergan said.

Levadex is actually a new form of an old drug, known as dihydroergotamine, or DHE, which has been used to treat severe migraine attacks for decades. DHE is typically given by intravenous infusion, requiring patients to get to a hospital at a time when many would rather remain in a dark quiet room.

Levadex, by contrast, is breathed into the lungs using an inhaler similar to one used for asthma, allowing people to use it at home.

The F.D.A. declined to approve Levadex last March, though MAP said the rejection was related to manufacturing and questions about use of the inhaler, not the safety and efficacy of the drug. It resubmitted its application, with additional data and answers to questions from the F.D.A., in October.

Levadex would be the first approved product for MAP, which is based in Mountain View, Calif.

Allergan said that if Levadex is approved by April, the transaction would dilute earnings by about 7 cents a share in 2013 and add to earnings in the second half of 2014.

Allergan was advised by Goldman Sachs and the law firm Gibson, Dunn & Crutcher. MAP was advised by Centerview Partners and the law firm Latham & Watkins.

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IHT Rendezvous: IHT Quick Read: Jan. 22

NEWS Barack Hussein Obama ceremonially opened his second term on Monday with an assertive Inaugural Address that offered a robust articulation of modern liberalism in America, arguing that “preserving our individual freedoms ultimately requires collective action.” Peter Baker reports from Washington. The President made addressing climate change the most prominent policy vow of his second Inaugural Address, setting in motion what Democrats say will be a deliberately paced but aggressive campaign built around the use of his executive powers to sidestep Congressional opposition. Richard W. Stevenson and John M. Broder report.

As the death toll from the crisis in the Sahara rose sharply to 37, Algeria’s prime minister said that the hostage takers intended to kill all their captives and that the army saved many by attacking. Adam Nossiter reports from Algiers and Eric Schmitt from Washington.

Malian and French troops appeared to recapture two important central Malian towns on Monday, pushing back an advance by Islamist militants who have overrun the country’s northern half. Lydia Polgreen reports from Segou, Mali, and Peter Tinti reports from Diabaly.

A report from the International Labor Organization predicted jobless levels to rise to 202 million worldwide this year, and said that government budget-balancing was hurting employment. David Jolly reports from Paris.

Europe’s political leaders have taken important steps to improve spending discipline among euro members, but have yet to address some serious flaws in the structure of the euro zone. Liz Alderman reports from Paris and Jack Ewing from Frankfurt.

Chancellor Angela Merkel’s main rivals eked out a one-seat majority that will usher the opposition Social Democrats into power in the state of Lower Saxony. Melissa Eddy and Nicholas Kulish report from Berlin.

ARTS The Neues Museum in Berlin is celebrating a bust of the Egyptian queen Nefertiti that “fell” into its hands 100 years ago. Melissa Eddy reports.

FASHION Raf Simons sent out a Dior summer couture collection rooted in reality — note the model’s wash-’n'-go hair — but full of flowers and the beauty of nature. Suzy Menkes writes from Paris.

SPORTS Sloane Stephens’s reward for reaching her first Grand Slam quarterfinal will be a match against a friend and fellow American, Serena Williams. Christopher Clarey reports from Melbourne.

Golfers will be able to express their opinions during Tuesday’s PGA Tour players’ meeting on the proposed ban of the anchored putting stroke. Karen Crouse reports from San Diego.

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BlackBerry Z10 compared to iPhone 5 on camera [video]

Alongside BGR’s own extensive BlackBerry 10 walkthrough, Austrian website Telekom Presse has uploaded another video comparing Research in Motion’s (RIMM) not-so-secret BlackBerry Z10 smartphone to the iPhone 5. The company’s upcoming BlackBerry 10 operating system seems to be a mix between iOS and Android, while adding some unique features. The video showcases the BlackBerry voice assistant app, multitasking and app switching, the app drawer, and the device’s business and home profiles.

[More from BGR: BlackBerry 10 OS walkthrough, BlackBerry Z10 pricing]

Despite the fact that the handset is still running beta software it appears to be exceptionally fast, even besting the iPhone 5 in some scenarios.

[More from BGR: Rumored Xbox 720 specs: 8-core processor, 8GB of RAM, 800MHz GPU]

The BlackBerry Z10 smartphone is said to be equipped with a 4.2-inch HD display, 16GB of internal storage, an 8-megapixel rear camera, 2GB of RAM, NFC, 4G LTE and an 1,800 mAh battery.

RIM will unveil the device along with a second BlackBerry 10 phone at a press conference on January 30th. The BlackBerry Z10, iPhone 5 comparison video follows below.

This article was originally published on BGR.com

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Jim, John Harbaugh ready for rematch at Super Bowl

SANTA CLARA, Calif. (AP) — Jim and John Harbaugh have exchanged a handful of text messages, and plan to leave it at that. No phone conversations necessary while the season's still going. No time for pleasantries, even for the friendly siblings.

There is work to be done to prepare for the Super Bowl, prepare for each other, prepare for a history-making day already being widely hyped as "Harbowl" or "Superbaugh" depending which nickname you prefer.

"It doesn't matter who the coach is, what relationship you have with the person on the other side," 49ers coach Jim Harbaugh said so matter-of-factly Monday afternoon.

Their parents sure aren't picking sides for the Feb. 3 matchup in New Orleans.

These days, the Harbaughs' longtime coaching father, Jack, stays away from game-planning chatter or strategy sessions with his Super Bowl-bound coaching sons. Baltimore's John Harbaugh and little brother Jim have been doing this long enough now to no longer need dad's input.

Yet, they still regularly seek it. And, their father does offer one basic mantra: "Get ahead, stay ahead."

"Probably the greatest advice that I've ever been given and the only advice that I've ever found to be true in all of coaching, I think we mentioned it to both John and Jim ... the coaching advice is, 'Get ahead, stay ahead,'" Jack Harbaugh said.

"If I'm called upon, I'll repeat that same message."

His boys still call home regularly to check in with the man who turned both on to the coaching profession years ago, and the mother who has handled everything behind the scenes for decades in a highly competitive, sports-crazed family — with all the routine sports clichés to show for it.

The Harbaugh brothers will become the first siblings to square off from opposite sidelines when their teams play for the NFL championship at the Superdome.

Not that they're too keen on playing up the storyline that has no chance of going away as hard as they try.

"Well, I think it's a blessing and a curse," Jim Harbaugh said Monday. "A blessing because that is my brother's team. And, also, personally I played for the Ravens. Great respect for their organization. ... The curse part would be the talk of two brothers playing in the Super Bowl and what that takes away from the players that are in the game. Every moment that you're talking about myself or John, that's less time that the players are going to be talked about."

Both men love history, just not the kind with them making it.

"I like reading a lot of history ... I guess it's pretty neat," John Harbaugh offered Monday. "But is it really going to be written about? It's not exactly like Churchill and Roosevelt or anything. It's pretty cool, but that's as far as it goes."

Nice try, guys.

John watched the end of Jim's game from the field in Foxborough, Mass., as Baltimore warmed up for the AFC championship game. Jim called his sister's family from the team plane before takeoff after a win at Atlanta and asked how his big brother's team was doing against New England.

The improbable Super Bowl features a set of brothers known around the NFL as fierce competitors unafraid to make a bold move during the season. Unafraid to upset anyone who stands in their way.

In fact, each one made a major change midseason to get this far — John fired his offensive coordinator, while Jim boosted his offense with a quarterback switch from Alex Smith to Colin Kaepernick.

Leading up to Sunday's games, parents Jack and Jackie said they would wait to decide whether to travel to New Orleans if both teams advanced or stick to what has been working so well — watching from the comfort of their couch in Mequon, Wis.

"We enjoy it very much. We get down in our basement, turn on the television and just have a fantastic day watching outstanding football," Jack said last week. "We share our misery with no one but ourselves. Not only the misery, but the ups and downs, the ins and outs of an outstanding professional game."

And, no, the Harbaughs weren't looking ahead to a potential big trip to the Big Easy.

Jack insists his wife is quick to pull out that old sports cliche: "It's one game at a time. I think it's very appropriate," he said.

Jim figures they won't possibly miss this history-making game.

"I think they'll be there," he said with a smile.

The brothers, separated in age by 15 months, have taken different paths to football's biggest stage — years after their intense games of knee football at the family home. They tried to beat each other at cards, or whatever other game it was at the time. Sometimes, they tried to beat each other up. Sister, Joani Crean, often got in on the fun, too.

The 49-year-old Jim never reached a Super Bowl, falling a last-gasp pass short during a 15-year NFL career as a quarterback. The 50-year-old John never played in the NFL.

Still, both will tell you, "Who's got it better than us? No-body!" — one catchphrase they got from their dad.

"We can't put into words what it means to see John and Jim achieve this incredible milestone," their brother-in-law, Indiana basketball coach Tom Crean, said on Twitter. "We talked to Jim (before) his team plane left. All he wanted to know was how was John doing? How were they playing? One incredible family who puts the care, well-being and love for each other at the forefront like most families do. Again, we are very proud of them. Going to be exciting to watch it unfold."

John worked his way up from the bottom of the coaching ranks, while Jim was the star college quarterback at Michigan, a first-round draft pick and eventual Pro Bowler who made coaching his career once he retired.

John already has the one-up, while Jim's team is the early favorite. John's Ravens beat the 49ers 16-6 on Thanksgiving night 2011, in Jim's rookie season as an NFL coach — though both know that means nothing now.

"I just want everybody to know, that was a four-day deal and every story has been told," John said. "We're not that interesting. There's nothing more to learn. The tape across the middle of the room story, OK, you got it? It's OK. It was just like any other family, really. I really hope the focus is not so much on that. We get it, it's really cool and it's exciting and all that."

Said Jim, "Completely new business."

In spite of his efforts to avoid the topic, Jim did take the opportunity to express how proud he is of John.

"He's a great football coach, a real grasp of all phases — offense, defense, special teams. I think he could coordinate at least two of those phases and do it as well as anyone in the league," Jim said. "I've got half the amount of coaching experience he does. Again, it's not about us. I keep coming back to that. I'm really proud of my brother. I love him. That's the blessing part, that this is happening to him."

And, fittingly for the big brother, John feels the exact same way.

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AP Sports Writer Dave Ginsburg in Baltimore contributed to this story.

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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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